Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

The ability to make decisions and act quickly without hesitation can be advantageous in
many settings. However, when persistently expressed, impulsive decisions and actions are …

The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Background As greater numbers of us are living longer, it is increasingly important to
understand how we can age healthily. Although old age is often stereotyped as a time of …

Parkinson's disease causes a characteristic combination of motor symptoms due to
progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars …

The locus coeruleus (LC) contains norepinephrine (NE)-synthesizing neurons that send
diffuse projections throughout the central nervous system. The LC-NE system has a major …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

Communication between the prefrontal cortex and subcortical nuclei underpins the control
and inhibition of behavior. However, the interactions in such pathways remain controversial …

Background Neurodegeneration in the locus coeruleus (LC) contributes to neuropsychiatric
symptoms in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP) …