As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs)
have emerged as a versatile and frequently utilized cell source in the fields of regenerative …

Background Foetal bovine serum (FBS), is the most commonly used culture medium additive
for in vitro cultures, despite its undefined composition, its potential immunogenicity and …

Mesenchymal stem cell (MSC) culturing for cell therapies needs a step forward to be
routinely used in clinical settings. Main concerns regard the use of animal origin reagents, in …

Background: Platelet-rich plasma (PRP) refers to an enriched platelet suspension in plasma.
In addition to the clinical application of PRP in the context of various orthopedic diseases …

Culture expansion of primary cells evokes highly reproducible DNA methylation (DNAm)
changes. We have identified CG dinucleotides (CpGs) that become continuously hyper-or …

Background Adipose tissue-derived mesenchymal stromal cells (ASCs) have been shown to
exhibit some promising properties of their use in regenerative medicine as advanced …

The aim of this clinical trial (ID Number NCT01803347) was to determine the safety and
efficacy of autologous adipose-derived stem cells (ASCs) for treatment of cryptoglandular …

In vitro two-dimensional (2D) and three-dimensional (3D) cultivation of mammalian cells
requires supplementation with serum. Mesenchymal stem cells (MSCs) are widely used in …

Background Senolytic drugs are thought to target senescent cells and might thereby
rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan …

Background The complex composition of different cell types within a tissue can be estimated
by deconvolution of bulk gene expression profiles or with various single-cell sequencing …