Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel
biomedical application for microfluidic based devices has emerged in recent years and …

An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …

Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

The way in which a cell migrates is influenced by the physical properties of its surroundings,
in particular the properties of the extracellular matrix. How the physical aspects of the cell's …

Highlights•Comprehensive review of advances in microfluidic 3D cell culture since
2012.•Increased physiological relevance by precise control of cellular microenvironment.• …

Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …

Arterial thrombosis is the main instigating factor of heart attacks and strokes, which result in
over 14 million deaths worldwide every year. The mechanism of thrombosis involves factors …

In recognition of the enormous potential of immunotherapies against cancer, research into
the interactions between tumor and immune cells has accelerated, leading to the recent FDA …

As a 3D bioprinting technique, hydrogel stereolithography has historically been limited in its
ability to capture the spatial heterogeneity that permeates mammalian tissues and dictates …

Tumor cells that disseminate from the primary tumor and survive the vascular system can
eventually extravasate across the endothelium to metastasize at a secondary site. In this …