Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …

Simple Summary Most malignant tumours are highly heterogeneous at molecular and
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …

Methods| The Johns Hopkins Hospital research autopsy program4 includes institutional
review board-approved autopsy of COVID-19–positive (nasal swab, Cepheid GeneXpert …

Clinical trials represent a fulcrum for oncology drug discovery and development to bring safe
and effective medicines to patients in a timely manner. Clinical trials have shifted from …

Simple Summary The incidence of prostate cancer (PC) is statistically biased due to the
increase in prostate-specific antigen (PSA) screening and the accuracy of national cancer …

While there is a great clinical need to understand the biology of metastatic cancer in order to
treat it more effectively, research is hampered by limited sample availability. Research …

Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound
competent latent and transcriptionally active reservoir cells persevere despite antiretroviral …

Introduction The question of what motivates people to participate in research is particularly
salient in the HIV field. While participation in HIV research was driven by survival in the …

Pancreatic ductal adenocarcinoma (PDAC) is the most common and aggressive type of
pancreatic cancer. The five-year survival rate of PDAC is very low (less than 8%), which is …

Each rapid autopsy is a powerful opportunity to supply multiple researchers with many
valuable tissue specimens at the same time. Since the beginning of the development of …