Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The response‐to‐retention hypothesis of atherogenesis reinforced

KJ Williams, I Tabas - Current opinion in lipidology, 1998 - journals.lww.com
Many lines of evidence indicate that the key initiating event in early atherosclerosis is the
subendothelial retention of cholesterol‐rich, atherogenic lipoproteins. Once retained, these …

Role of monocytes in atherogenesis

B Østerud, E Bjørklid - Physiological reviews, 2003 - journals.physiology.org
Østerud, Bjarne, and Eirik Bjørklid. Role of Monocytes in Atherogenesis. Physiol Rev 83:
1069-1112, 2003; 10.1152/physrev. 00005.2003.—This review focuses on the role of …

Adhesion molecules and atherogenesis

Y Huo, K Ley - Acta Physiologica Scandinavica, 2001 - Wiley Online Library
Atherosclerosis is an inflammatory disease of the vessel wall characterized by monocyte
infiltration in response to pro‐atherogenic factors such as oxidized lipids. Recently, the role …

[HTML][HTML] High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway: a possible mechanism for protection against atherosclerosis by HDL

P Xia, MA Vadas, KA Rye, PJ Barter… - Journal of Biological …, 1999 - ASBMB
The ability of high density lipoproteins (HDL) to inhibit cytokine-induced adhesion molecule
expression has been demonstrated in their protective function against the development of …

Cellular adhesion molecules on vascular smooth muscle cells

M Braun, P Pietsch, K Schrör, G Baumann… - Cardiovascular …, 1999 - academic.oup.com
Several studies during the last years have shown that, in addition to endothelial cells,
vascular smooth muscle cells also express the cellular adhesion molecules ICAM-1 and …

Nonoxidative modifications of lipoproteins in atherogenesis

I Tabas - Annual review of nutrition, 1999 - annualreviews.org
▪ Abstract The key initiating event in atherosclerosis is the retention of plasma lipoproteins in
the subendothelial matrix. Subsequently, a series of biological responses to this retained …

Lipids and the endothelium

AM Dart, JPF Chin-Dusting - Cardiovascular research, 1999 - academic.oup.com
The normal endothelium is characterised by the production of a number of molecules which
affect the contractile state of adjacent myocytes and the behavior of formed elements within …

[PDF][PDF] Postprandial lipoproteins and atherosclerosis

KC Yu, AD Cooper - Front Biosci, 2001 - article.imrpress.com
[Frontiers in Bioscience 6, d332-354, March 1, 2001] 332 POSTPRANDIAL LIPOPROTEINS
AND ATHEROSCLEROSIS Kenneth CW. Yu 1 and All Page 1 [Frontiers in Bioscience 6 …

Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosis

CA Gleissner, N Leitinger, K Ley - Hypertension, 2007 - Am Heart Assoc
Atherosclerosis is a chronic inflammatory disease of the arterial wall1–3 with enormous
epidemiological relevance. 4, 5 Recruitment of monocytes to the vascular wall is a key …