Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

The pancreas originates from two epithelial evaginations of the foregut, which consist of
multipotent epithelial progenitors that organize into a complex tubular epithelial network …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

The Notch signalling pathway plays a crucial role in specifying cellular fates in metazoan
development by regulating communication between adjacent cells,. Correlative studies …

Novel strategies in diabetes therapy would obviously benefit from the use of beta (β) cell
stem/progenitor cells. However, whether or not adult β cell progenitors exist is one of the …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The
mammalian Hes basic helix-loop-helix repressor genes play central roles in these …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …