Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is
characterized by the deficits in the cholinergic system and deposition of beta amyloid (Aβ) in …

Acetylcholinesterase is a member of the α/β hydrolase protein super family, with a significant
role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs …

Photocatalytic carboxylation of alkenes with CO2 is a promising and sustainable strategy to
synthesize high value-added carboxylic acids. However, it is challenging and rarely …

The conformational restriction (rigidification) of a flexible ligand has often been a commonly
used strategy in drug design, as it can minimize the entropic loss associated with the ligand …

In the brain, acetylcholine (ACh) is regarded as one of the major neurotransmitters. During
the advancement of Alzheimer's disease (AD) cholinergic deficits occur and this can lead to …

ABSTRACT Introduction: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes
acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline …

Acetylcholinesterase is an enzyme associated with senile plaques. Biochemical studies
have indicated that acetylcholinesterase induces amyloid fibril formation by interaction …

The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system (CNS) which is the most common cause of dementia in the elderly. It is …

Alzheimer s disease (AD) is a complex multifactorial syndrome unlikely to arise from a single
causal factor, but due to a number of different but related biological alterations that …