Abstract Tumor progression locus 2 (TPL2, also known as COT or MAP3K8) is a mitogen-
activated protein kinase kinase (MAP3 K) activated downstream of TNFαR, IL1R, TLR …

Macrophages are immune system cells that respond to various pathogenic insults. The
recognition of antigens is performed through receptors such as TLR4 and RAGE, which …

Over the years, tumor progression locus 2 (TPL2) has been identified as an essential
modulator of immune responses that conveys inflammatory signals to downstream effectors …

Mastitis is the most prevalent disease in dairy cattle worldwide and not only causes huge
economic losses in the dairy industry but also threatens public health. To evaluate the …

Mesenchymal stem cells (MSCs) are pluripotent cells that can differentiate into multilineage
cell types, including adipocytes and osteoblasts. Mechanical stimulus is one of the crucial …

Proinflammatory cytokine production by innate immune cells plays a crucial role in
inflammatory diseases, but the molecular mechanisms controlling the inflammatory …

M1 polarization of macrophages works as a promoter in pathogenesis of acute lung
injury/acute respiratory distress syndrome (ALI/ARDS) by the secretion of pro-inflammatory …

Tumor progression locus-2 (Tpl2) kinase is a major inflammatory mediator in immune cell
types recently found to be genetically associated with inflammatory bowel diseases (IBDs) …

ABSTRACT HIV-1 has a broad range of nuanced interactions with the immune system, and
the incorporation of cellular proteins by nascent virions continues to redefine our …

Abstract p38 MAPK signaling has been implicated in the regulation of processes leading to
cancer development and progression. Chronic inflammation is a known risk factor for …