Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
OD Howes, C Cummings, GE Chapman… - …, 2023 - nature.com
Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders
Observational studies have reported the correlations between brain imaging-derived
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …
Schizophrenia: from neurochemistry to circuits, symptoms and treatments
Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …
Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11. 2 deletion syndrome: a review of ENIGMA …
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
A systematic review and meta-analysis of structural and functional brain alterations in individuals with genetic and clinical high-risk for psychosis and bipolar disorder
LP Luna, J Radua, L Fortea, G Sugranyes… - Progress in Neuro …, 2022 - Elsevier
Neuroimaging findings in people at either genetic risk or at clinical high-risk for psychosis
(CHR-P) or bipolar disorder (CHR-B) remain unclear. A meta-analytic review of whole-brain …
(CHR-P) or bipolar disorder (CHR-B) remain unclear. A meta-analytic review of whole-brain …
A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the …
Schizophrenia is associated with widespread alterations in subcortical brain structure. While
analytic methods have enabled more detailed morphometric characterization, findings are …
analytic methods have enabled more detailed morphometric characterization, findings are …
What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group
MRI‐derived brain measures offer a link between genes, the environment and behavior and
have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of …
have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of …
[HTML][HTML] On the origins of schizophrenia
RS Kahn - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
What have we accomplished for schizophrenia patients since the introduction of
chlorpromazine in 1952 (1)? Have we really made a difference in the outcome of …
chlorpromazine in 1952 (1)? Have we really made a difference in the outcome of …
Polygenic risk and progression to bipolar or psychotic disorders among individuals diagnosed with unipolar depression in early life
Objective: The authors investigated the associations between polygenic liability and
progression to bipolar disorder or psychotic disorders among individuals diagnosed with …
progression to bipolar disorder or psychotic disorders among individuals diagnosed with …