Pathogenesis of allergic diseases and implications for therapeutic interventions

J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

[HTML][HTML] Nociceptor neurons affect cancer immunosurveillance

M Balood, M Ahmadi, T Eichwald, A Ahmadi… - Nature, 2022 - nature.com
Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory
peripheral nervous systems,,,–. Whether the neo-innervation of tumours by pain-initiating …

Cutaneous neuroimmune interactions in peripheral neuropathic pain states

DB Lowy, PGS Makker, G Moalem-Taylor - Frontiers in Immunology, 2021 - frontiersin.org
Bidirectional interplay between the peripheral immune and nervous systems plays a crucial
role in maintaining homeostasis and responding to noxious stimuli. This crosstalk is …

Neuroimmune interactions in the lung

R Azzoni, O Perdijk, NL Harris… - Annual Review of …, 2023 - annualreviews.org
Barrier tissues are highly innervated by sensory and autonomic nerves that are positioned in
close proximity to both stromal and immune cell populations. Together with a growing …

Pathogenesis of children's allergic diseases: refocusing the role of the gut microbiota

T Hu, Y Dong, C Yang, M Zhao, Q He - Frontiers in physiology, 2021 - frontiersin.org
Allergic diseases comprise a genetically heterogeneous cluster of immunologically
mediated diseases, including asthma, food allergy (FA), allergic rhinitis (AR) and eczema …

Neuro-immune regulation in inflammation and airway remodeling of allergic asthma

N Zhang, J Xu, C Jiang, S Lu - Frontiers in Immunology, 2022 - frontiersin.org
Allergic asthma is a common chronic inflammation of the airways and causes airway
remodeling eventually. For a long time, investigators have been focusing on the …

Further understanding of neuro-immune interactions in allergy: implications in pathophysiology and role in disease progression

GN Konstantinou, GN Konstantinou… - Journal of Asthma …, 2022 - Taylor & Francis
The complicated interaction between the central and the autonomic (sympathetic,
parasympathetic, and enteric) nervous systems on the one hand and the immune system …

Nasal airway microRNA profiling of infants with severe bronchiolitis and risk of childhood asthma: a multicentre prospective study

Z Zhu, RJ Freishtat, B Harmon, A Hahn… - European …, 2023 - Eur Respiratory Soc
Background Severe bronchiolitis (ie bronchiolitis requiring hospitalisation) during infancy is
a major risk factor for childhood asthma. However, the exact mechanism linking these …

[HTML][HTML] Ambient ozone, and urban PM2. 5 co-exposure, aggravate allergic asthma via transient receptor potential vanilloid 1-mediated neurogenic inflammation

Z Lian, H Qi, X Liu, Y Zhang, R Xu, X Yang… - Ecotoxicology and …, 2022 - Elsevier
Allergic asthma is the most common pulmonary inflammatory disease, and epidemiological
studies have revealed that PM 2.5 or ambient ozone (O 3) exposure contribute to the higher …

Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker

I Tochitsky, S Jo, N Andrews, M Kotoda… - British journal of …, 2021 - Wiley Online Library
Background and Purpose Many pain‐triggering nociceptor neurons express TRPV1 or
TRPA1, cation‐selective channels with large pores that enable permeation of QX‐314, a …