Oxidative stress and assisted reproduction: a comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment
A Agarwal, I Maldonado Rosas, C Anagnostopoulou… - Antioxidants, 2022 - mdpi.com
Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and
antioxidants has been established as an important factor that can negatively affect the …
antioxidants has been established as an important factor that can negatively affect the …
Defining physiological normoxia for improved translation of cell physiology to animal models and humans
TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
[HTML][HTML] Complete human day 14 post-implantation embryo models from naive ES cells
The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …
and technical challenges associated with intrauterine development after implantation …
Deciphering the “m6A code” via antibody-independent quantitative profiling
MA Garcia-Campos, S Edelheit, U Toth, M Safra… - Cell, 2019 - cell.com
Summary N6-methyladenosine (m 6 A) is the most abundant modification on mRNA and is
implicated in critical roles in development, physiology, and disease. A major limitation has …
implicated in critical roles in development, physiology, and disease. A major limitation has …
Distinct processing of lncRNAs contributes to non-conserved functions in stem cells
Long noncoding RNAs (lncRNAs) evolve more rapidly than mRNAs. Whether conserved
lncRNAs undergo conserved processing, localization, and function remains unexplored. We …
lncRNAs undergo conserved processing, localization, and function remains unexplored. We …
[HTML][HTML] Autophagy promotes cell survival by maintaining NAD levels
Autophagy is an essential catabolic process that promotes the clearance of surplus or
damaged intracellular components. Loss of autophagy in age-related human pathologies …
damaged intracellular components. Loss of autophagy in age-related human pathologies …
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
F Soldner, Y Stelzer, CS Shivalila, BJ Abraham… - Nature, 2016 - nature.com
Genome-wide association studies (GWAS) have identified numerous genetic variants
associated with complex diseases, but mechanistic insights are impeded by a lack of …
associated with complex diseases, but mechanistic insights are impeded by a lack of …
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency
Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …
[HTML][HTML] Induction of expansion and folding in human cerebral organoids
An expansion of the cerebral neocortex is thought to be the foundation for the unique
intellectual abilities of humans. It has been suggested that an increase in the proliferative …
intellectual abilities of humans. It has been suggested that an increase in the proliferative …
Derivation of novel human ground state naive pluripotent stem cells
O Gafni, L Weinberger, AAF Mansour, YS Manor… - Nature, 2013 - nature.com
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and
can be preserved in vitro in a naive inner-cell-mass-like configuration by providing …
can be preserved in vitro in a naive inner-cell-mass-like configuration by providing …