Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …

Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of
the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in …

Humans detect skin temperature changes that are perceived as warm or cool. Like humans,
mice report forepaw skin warming with perceptual thresholds of less than 1° C and do not …

Energy balance—that is, the relationship between energy intake and energy expenditure—
is regulated by a complex interplay of hormones, brain circuits and peripheral tissues. Leptin …

The ability to feel the warmth of the sun or the coolness of a breeze on a summer's day; a
pleasant caress of skin; to explore the texture, size, and shape of an object; and to feel pain …

The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …

Obesity and overweight are major health issues. Exercise and calorie intake control are
recognized as the primary mechanisms for addressing excess body weight. Naturally …

Avian cold adaptation is hallmarked by innovative strategies of both heat conservation and
thermogenesis. While minimizing heat loss can reduce the thermogenic demands of body …

Thermogenesis, the production of heat energy, is an essential component of the homeostatic
repertoire to maintain body temperature during the challenge of low environmental …