Anticancer activity of chitosan, chitosan derivatives, and their mechanism of action

HS Adhikari, PN Yadav - International Journal of Biomaterials, 2018 - Wiley Online Library
Tailoring of chitosan through the involvement of its amino, acetamido, and hydroxy groups
can give derivatives of enhanced solubility and remarkable anticancer activity. The general …

Ferrocene-containing hybrids as potential anticancer agents: Current developments, mechanisms of action and structure-activity relationships

R Wang, H Chen, W Yan, M Zheng, T Zhang… - European Journal of …, 2020 - Elsevier
Cancer is one of the most fatal threatens to human health throughout the world. The major
challenges in the control and eradication of cancers are the continuous emergency of drug …

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

Ferrocene-appended pharmacophores: An exciting approach for modulating the biological potential of organic scaffolds

A Singh, I Lumb, V Mehra, V Kumar - Dalton transactions, 2019 - pubs.rsc.org
Two exemplary contributions of organometallics in medicinal chemistry, ferroquine and
ferrocifen, which exhibit excellent anti-plasmodial and anti-cancer activities, respectively …

Ferrocenyl-nucleobase complexes: Synthesis, chemistry and applications

K Kowalski - Coordination Chemistry Reviews, 2016 - Elsevier
Ferrocenyl-nucleobases are an increasingly important class of complexes with possible
applications in biology, pharmacy and material sciences. This review focuses on synthetic …

β-Lactams as promising anticancer agents: Molecular hybrids, structure activity relationships and potential targets

DJ Fu, YF Zhang, AQ Chang, J Li - European Journal of Medicinal …, 2020 - Elsevier
Abstract β-Lactam, commonly referred as azetidin-2-one, is a multifunctional building block
for synthesizing β-amino ketones, γ-amino alcohols, and other compounds. Besides its well …

Recent advancements in uracil and 5-fluorouracil hybrids as potential anticancer agents: A review

M Sanduja, J Gupta, T Virmani - Journal of Applied Pharmaceutical …, 2020 - japsonline.com
Cancer is the most dreadful disease and the second main cause of death worldwide. The
continuous developments have been going on in order to design potent molecules such that …

Flavonoid-metal ion complexes as potent anticancer metallodrugs: a comprehensive review

SB Zangade, BS Dhulshette… - Mini Reviews in Medicinal …, 2024 - ingentaconnect.com
Background: Flavonoids and their analogous are mainly found in pink lady apples, green
and black tea (catechins), celery and red peppers, onions, broccoli and spinach, berries …

Synthesis and biological evaluations of mono‐and bis‐ferrocene uracil derivatives

S Djaković, L Glavaš‐Obrovac, J Lapić… - Applied …, 2021 - Wiley Online Library
Mono‐(3a–3e and 4a–4e) and bis‐ferrocene (5a–5e and 6a–6e) conjugated 5‐substituted
uracil derivatives that are bridged by 1, 2, 3‐triazole linker were synthesized. The impact of …

Synthesis, docking, machine learning and antiproliferative activity of the 6-ferrocene/heterocycle-2-aminopyrimidine and 5-ferrocene-1H-Pyrazole derivatives obtained …

E Venturini Filho, JWS Pina, MK Antoniazi… - Bioorganic & Medicinal …, 2021 - Elsevier
A simple and fast methodology under microwave irradiation for the synthesis of 2-
aminopyrimidine and pyrazole derivatives using Atwal reaction is reported. After the …