Exome sequencing has been commonly used to characterize rare diseases by selecting
multiplex families or singletons with an extreme phenotype (EP) and searching for rare …

Tinnitus can be a burdensome condition on both individual and societal levels. Many
aspects of this condition remain elusive, including its underlying mechanisms, ultimately …

Importance Tinnitus affects at least 16 million US adults, but its pathophysiology is
complicated, and treatment options remain limited. A heritable component has been …

Tinnitus, a phantom perception of sound in the absence of any external sound source, is a
prevalent health condition often accompanied by psychiatric comorbidities. Recent genome …

Importance No effective treatments are currently available for severe tinnitus, which affects
1% of the population and lowers the quality of life. The factors that contribute to the transition …

Background tinnitus is a heterogeneous condition associated with audiological and/or
mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a …

Tinnitus is the perception of a phantom sound that affects between 10 and 15% of the
general population. Despite this considerable prevalence, treatments for tinnitus are …

Subjective tinnitus, the perception of sound in the absence of any sound source, is routinely
assessed using questionnaires. The subjective nature of these tools hampers objective …

Importance: Chronic subjective tinnitus, the perception of sound without an external source
for longer than six months, may be a greatly debilitating condition for some people, and is …

Objective: Tinnitus is associated with various conditions such as presbycusis, infectious,
autoimmune and many other diseases. Our study aims to identify an association between …