Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Background Gene drives based on CRISPR-Cas9 technology are increasingly being
considered as tools for reducing the capacity of mosquito populations to transmit malaria …

The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow
fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually …

The CRISPR-Cas system is a powerful tool for in vivo editing the genome of most organisms,
including man. During the years this technique has been applied in several fields, such as …

Synthetic gene drive constructs could, in principle, provide the basis for highly efficient
interventions to control disease vectors and other pest species. This efficiency derives in part …

Gene drive technology, in which fast‐spreading engineered drive alleles are introduced into
wild populations, represents a promising new tool in the fight against vector‐borne diseases …

Synthetic gene drive (GD) systems constitute a form of novel invasive environmental
biotechnology with far-reaching consequences beyond those of other known genetically …

The ability to engineer gene drives (genetic elements that bias their own inheritance) has
sparked enthusiasm and concerns. Engineered gene drives could potentially be used to …

A synthetic gene drive that targets haplolethal genes on the X chromosome can skew the
sex ratio toward males. Like an “X-shredder,” it does not involve “homing,” and that has …