Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Epigenetics in health and disease
L Zhang, Q Lu, C Chang - Epigenetics in allergy and autoimmunity, 2020 - Springer
Epigenetic mechanisms, which include DNA methylation, histone modification, and
microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA …
microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA …
Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
The ageing epigenome and its rejuvenation
Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …
The continuum of aging and age-related diseases: common mechanisms but different rates
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
The promise of adolescence: Realizing opportunity for all youth
EP Backes, RJ Bonnie - 2019 - books.google.com
Adolescenceâ€" beginning with the onset of puberty and ending in the mid-20sâ€" is a
critical period of development during which key areas of the brain mature and develop …
critical period of development during which key areas of the brain mature and develop …
Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer
WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis
Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …