[HTML][HTML] Physiologically Based Pharmacokinetics Modeling in the Neonatal Population—Current Advances, Challenges, and Opportunities
Physiologically based pharmacokinetic (PBPK) modeling is an approach to predicting drug
pharmacokinetics, using knowledge of the human physiology involved and drug …
pharmacokinetics, using knowledge of the human physiology involved and drug …
[HTML][HTML] Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic …
Tacrolimus is a crucial immunosuppressant for organ transplant patients, requiring
therapeutic drug monitoring due to its variable exposure after oral intake. Physiologically …
therapeutic drug monitoring due to its variable exposure after oral intake. Physiologically …
Identification of a Safe and Tolerable Carbamazepine Dosing Paradigm that Facilitates Effective Evaluation of CYP3A4 Induction
A Datta‐Mannan, E Shanks, E Yuen… - Clinical …, 2024 - Wiley Online Library
Carbamazepine (CBZ) is the recommended alternative to rifampicin as a CYP3A4 inducer in
drug–drug interaction studies. However, the traditional CBZ dosing paradigm can lead to …
drug–drug interaction studies. However, the traditional CBZ dosing paradigm can lead to …
Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4—A Case Study with …
AC Ozbey, J Keemink, B Wagner, A Pugliano… - Drug Metabolism and …, 2024 - ASPET
Hepatic impairment, due to liver cirrhosis, decreases the activity of cytochrome P450
enzymes (CYPs). The use of physiologically based pharmacokinetic (PBPK) modeling to …
enzymes (CYPs). The use of physiologically based pharmacokinetic (PBPK) modeling to …
Prediction of Pediatric Pharmacokinetics for CYP3A4 Metabolized Drugs: Comparison of the Performance of Two Hepatic Ontogeny Within a Physiologically Based …
M Codaccioni, RL Southall, J Dinh… - The Journal of Clinical …, 2024 - Wiley Online Library
The rapid growth in the use of pediatric physiologically based pharmacokinetic (PBPK)
models, particularly for regulatory applications, has focused emphasis on model verification …
models, particularly for regulatory applications, has focused emphasis on model verification …
Development and Verification of a Japanese Pediatric Physiologically Based Pharmacokinetic Model with Emphasis on Drugs Eliminated by Cytochrome P450 or …
TN Johnson, K Abduljalil, X Pan… - The Journal of Clinical …, 2023 - Wiley Online Library
Physiologically based pharmacokinetic (PBPK) models are useful in bridging drug exposure
in different ethnic groups, and there is increasing regulatory application of this approach in …
in different ethnic groups, and there is increasing regulatory application of this approach in …