The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Enteroendocrine cells (EECs) control a wide range of physiological processes linked to
metabolism. We show that EEC hormones are differentially expressed between crypts (for …

The intestinal epithelium must balance efficient absorption of nutrients with partitioning
commensals and pathogens from the bodies' largest immune system. If this crucial barrier …

The capacity of the 3D-organoid cultures to resemble a near-physiological tissue
organization and to mimic–to a certain degree–organ functionality, make organoids an …

Abstract Objective Bile acids (BAs) facilitate fat absorption and may play a role in glucose
and metabolism regulation, stimulating the secretion of gut hormones. The relative …

Enteroendocrine cells (EECs) produce hormones such as glucagon-like peptide 1 and
peptide YY that regulate food absorption, insulin secretion, and appetite. Based on the …

Enteroendocrine cells were historically classified by a letter code, each linked to a single
hormone, deduced to be the only hormone produced by the cell. One type, the L cell, was …

Enteroendocrine cells are specialized sensory cells of the gut-brain axis that are sparsely
distributed along the intestinal epithelium. The functions of enteroendocrine cells have …

Abstract Objective Insulin-like peptide-5 (INSL5) is an orexigenic gut hormone found in a
subset of colonic and rectal enteroendocrine L-cells together with the anorexigenic …