Premature birth is a significant cause of infant and child morbidity and mortality. In the United
States, the premature birth rate, which had steadily increased during the 1990s and early …

Importance Hypoxic-ischemic encephalopathy (HIE) occurs in 1 to 8 per 1000 live births in
developed countries. Historically, the clinician has had little to offer neonates with HIE other …

Background Although therapeutic hypothermia reduces death or disability after neonatal
encephalopathy in high-income countries, its safety and efficacy in low-income and middle …

Background In the Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY),
newborns with asphyxial encephalopathy who received hypothermic therapy had improved …

Background Therapeutic hypothermia (TH) is regarded as the most efficacious therapy for
neonatal hypoxic encephalopathy. However, limitations in previous systematic reviews and …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …

Background In neonatal encephalopathy, the clinical manifestations of injury can only be
reliably assessed several years after an intervention, complicating early prognostication and …

Aim To examine the relationship between electrographic seizures and long‐term outcome in
neonates with hypoxic–ischemic encephalopathy (HIE). Method Full‐term neonates with HIE …

This review discusses an approach to determining the cause of neonatal encephalopathy,
as well as current evidence on resuscitation and subsequent management of hypoxic …

Background Moderate cooling after birth asphyxia is associated with substantial reductions
in death and disability, but additional therapies might provide further benefit. We assessed …