Microneedles for painless transdermal immunotherapeutic applications

H Amani, MA Shahbazi, C D'Amico, F Fontana… - Journal of Controlled …, 2021 - Elsevier
Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in
the treatment of various diseases. However, owing to the dynamic nature of the immune …

[HTML][HTML] Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum

A Zaid Alkilani, MTC McCrudden, RF Donnelly - Pharmaceutics, 2015 - mdpi.com
The skin offers an accessible and convenient site for the administration of medications. To
this end, the field of transdermal drug delivery, aimed at developing safe and efficacious …

Transdermal microneedles for the programmable burst release of multiple vaccine payloads

KTM Tran, TD Gavitt, NJ Farrell, EJ Curry… - Nature Biomedical …, 2021 - nature.com
Repeated bolus injections are associated with higher costs and poor compliance and can
hinder the implementation of global immunization campaigns. Here, we report the …

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

S Mitragotri, PA Burke, R Langer - Nature reviews Drug discovery, 2014 - nature.com
The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …

Microneedles for drug and vaccine delivery

YC Kim, JH Park, MR Prausnitz - Advanced drug delivery reviews, 2012 - Elsevier
Microneedles were first conceptualized for drug delivery many decades ago, but only
became the subject of significant research starting in the mid-1990's when microfabrication …

Engineering microneedle patches for vaccination and drug delivery to skin

MR Prausnitz - Annual review of chemical and biomolecular …, 2017 - annualreviews.org
Microneedle patches (MNPs) contain arrays of solid needles measuring hundreds of
microns in length that deliver drugs and vaccines into skin in a painless, easy-to-use …

An overview of clinical and commercial impact of drug delivery systems

AC Anselmo, S Mitragotri - Journal of Controlled Release, 2014 - Elsevier
Drug delivery systems are widely researched and developed to improve the delivery of
pharmaceutical compounds and molecules. The last few decades have seen a marked …

Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

AS Rzhevskiy, TRR Singh, RF Donnelly… - Journal of controlled …, 2018 - Elsevier
Microneedles is the technique of drug delivery enhancement, which was primarily designed
for facilitating percutaneous drug delivery. Started from the development of simple solid …

Micro-scale devices for transdermal drug delivery

A Arora, MR Prausnitz, S Mitragotri - International journal of pharmaceutics, 2008 - Elsevier
Skin makes an excellent site for drug and vaccine delivery due to easy accessibility, immuno-
surveillance functions, avoidance of macromolecular degradation in the gastrointestinal tract …

[HTML][HTML] KASL clinical practice guidelines: management of hepatitis C

Korean Association for the Study of the … - Clinical and …, 2016 - ncbi.nlm.nih.gov
Aims The Korean Association for the Study of the Liver (KASL) Practice Guidelines for
Management of Hepatitis C were first established in 2004, and revised in 2013, when direct …