Driver mutations promote initiation and progression of cancer. Pharmacological treatment
can inhibit the action of the mutant protein; however, drug resistance almost invariably …

The primary physiological process of respiration produces carbon dioxide (CO 2) that reacts
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …

Inherent or acquired resistance to sotorasib poses a substantialt challenge for NSCLC
treatment. Here, we demonstrate that acquired resistance to sotorasib in isogenic cells …

Despite encouraging progress in the development of in vitro cancer models, in vitro cancer
models that simultaneously recapitulate the complexity of the tumor microenvironment and …

Elucidating the design principles of regulatory networks driving cellular decision-making has
fundamental implications in mapping and eventually controlling cell-fate decisions. Despite …

Novel inhibitors targeting Kirsten rat sarcoma virus homolog (KRAS) KRAS G12C in various
cancers have shown good initial efficacy, but therapy-related drug resistance eventually …

Purinergic signalling, consisting of extracellular purines and purinergic receptors, modulates
cell proliferation, invasion and immunological reaction during cancer progression. Here, we …

Translational research in medicine, defined as the transfer of knowledge and discovery from
the basic sciences to the clinic, is typically achieved through interactions between members …

Human cancer has been depicted as a non-linear dynamic system that is discontinuous in
space and time, but progresses through different sequential states (Figure 1)[1, 2]. Cancer …

The use of synthetic data is gaining an increasingly prominent role in data and machine
learning workflows to build better models and conduct analyses with greater statistical …