The duocarmycins (1 and 2) 1 belong to a small family of natural products (Figure 1) that
also include yatakemycin (3) 2 and CC-1065 (4). 3 Their exceptionally potent cytotoxic …

Antibody–drug conjugates (ADCs) that are currently on the market or in clinical trials are
predominantly based on two drug classes: auristatins and maytansinoids. Both are tubulin …

A Perspective of work in our laboratory on the examination of biologically active compounds,
especially natural products, is presented. In the context of individual programs and along …

A streamlined and efficient approach to the key epoxide intermediate for the asymmetric
synthesis of triazole antifungal agents is presented. This synthesis highlights a P (NMe2) 3 …

N-Acyl O-amino phenol derivatives of CBI-TMI and CBI-indole2 are reported as prototypical
members of a new class of reductively activated prodrugs of the duocarmycin and CC-1065 …

A unique heterocyclic carbamate prodrug of seco-CBI-indole2 that releases no residual
byproduct is reported as a new member of a class of hydrolyzable prodrugs of the …

A series of N-acyl O-amino derivatives of seco-CBI-indole2 are reported and examined as
prototypical members of a unique class of reductively activated (cleaved) prodrugs of the …

A short, asymmetric synthesis of the 1, 2, 9, 9a-tetrahydrocyclopropa [c] benzo [e] indol-4-
one (CBI) analogue of the CC-1065 and duocarmycin DNA alkylation subunits is described …

A short, asymmetric synthesis of the 1, 2, 9, 9a-tetrahydrocyclopropa [c] benzo [e] indol-4-
one (CBI) analogue of the CC-1065 and duocarmycin alkylation subunits is detailed that …

A summary of studies on the generation of acyl radicals and their subsequent use in
intermolecular, intramolecular, macrocyclization, and tandem alkene addition reactions is …