The role of the extracellular matrix in neural progenitor cell proliferation and cortical folding during human neocortex development

KR Long, WB Huttner - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Extracellular matrix (ECM) has long been known to regulate many aspects of neural
development in many different species. However, the role of the ECM in the development of …

Integrin signaling in the central nervous system in animals and human brain diseases

H Ikeshima-Kataoka, C Sugimoto… - International journal of …, 2022 - mdpi.com
The integrin family is involved in various biological functions, including cell proliferation,
differentiation and migration, and also in the pathogenesis of disease. Integrins are …

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

C Vinel, G Rosser, L Guglielmi, M Constantinou… - Nature …, 2021 - nature.com
Epigenetic mechanisms which play an essential role in normal developmental processes,
such as self-renewal and fate specification of neural stem cells (NSC) are also responsible …

Integrin-α9β1 as a novel therapeutic target for refractory diseases: Recent progress and insights

S Xu, T Zhang, Z Cao, W Zhong, C Zhang, H Li… - Frontiers in …, 2021 - frontiersin.org
Integrins refer to heterodimers consisting of subunits α and β. They serve as receptors on
cell membranes and interact with extracellular ligands to mediate intracellular molecular …

Generation of neural progenitor cells from canine induced pluripotent stem cells and preliminary safety test in dogs with spontaneous spinal cord injuries

L Chow, S McGrath, C de Arruda Saldanha… - Frontiers in Veterinary …, 2020 - frontiersin.org
Advances in stem cell technology, including the use of induced pluripotent stem cells (iPSC)
to produce neurons and glial cells, offer new hope for patients with neurological disease and …

The path to progress preclinical studies of age-related neurodegenerative diseases: a perspective on rodent and hiPSC-derived models

G MacDougall, LY Brown, B Kantor, O Chiba-Falek - Molecular Therapy, 2021 - cell.com
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent age-
related neurodegenerative diseases, and currently no effective clinical treatments exist for …

Valproic acid labeled chitosan nanoparticles promote the proliferation and differentiation of neural stem cells after spinal cord injury

D Wang, K Wang, Z Liu, Z Wang, H Wu - Neurotoxicity Research, 2021 - Springer
Chitosan nanoparticles and valproic acid are demonstrated as the protective agents in the
treatment of spinal cord injury (SCI). However, the effects of valproic acid-labeled chitosan …

Advances in human stem cell therapies: pre-clinical studies and the outlook for central nervous system regeneration

LH Forbes, MR Andrews - Neural Regeneration Research, 2021 - journals.lww.com
Cell transplantation has come to the forefront of regenerative medicine alongside the
discovery and application of stem cells in both research and clinical settings. There are …

干细胞疗法的进展和中枢神经系统再生的前景

LH Forbes, MR Andrews - 中国神经再生研究(英文版), 2021 - sjzsyj.com.cn
Cell transplantation has come to the forefront of regenerative medicine alongside the
discovery and application of stem cells in both research and clinical settings. There are …

OPN/IGF1 promotes the corticospinal tract regeneration by increasing neuron IGFR expression

Q ZHANG, K ZHANG, Z Zeng-Qiang… - Jie Fang Jun Yi Xue …, 2021 - search.proquest.com
Objectives To study the role and associated potential molecular mechanism of
osteopontin/insulin-like growth factor 1 (OPN/IGF1) in the corticospinal tract (CST) …