FOXP transcription factors in vertebrate brain development, function, and disorders

M Co, AG Anderson, G Konopka - Wiley Interdisciplinary …, 2020 - Wiley Online Library
FOXP transcription factors are an evolutionarily ancient protein subfamily coordinating the
development of several organ systems in the vertebrate body. Association of their genes …

A chromosome-level reference genome and pangenome for barn swallow population genomics

S Secomandi, GR Gallo, M Sozzoni, A Iannucci… - Cell reports, 2023 - cell.com
Insights into the evolution of non-model organisms are limited by the lack of reference
genomes of high accuracy, completeness, and contiguity. Here, we present a chromosome …

FOXP1 promotes embryonic neural stem cell differentiation by repressing Jagged1 expression

L Braccioli, SJ Vervoort, Y Adolfs, CJ Heijnen, O Basak… - Stem cell reports, 2017 - cell.com
Mutations in FOXP1 have been linked to neurodevelopmental disorders including
intellectual disability and autism; however, the underlying molecular mechanisms remain ill …

Cell type specializations of the vocal-motor cortex in songbirds

AA Nevue, BM Zemel, SR Friedrich, H von Gersdorff… - Cell reports, 2023 - cell.com
Identifying molecular specializations in cortical circuitry supporting complex behaviors, like
learned vocalizations, requires understanding of the neuroanatomical context from which …

Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish—implications for neurodevelopmental disorders

TM Lüffe, A D'Orazio, M Bauer, Z Gioga… - Translational …, 2021 - nature.com
Recent advances in the genetics of neurodevelopmental disorders (NDDs) have identified
the transcription factor FOXP2 as one of numerous risk genes, eg in autism spectrum …

Differential song deficits after lentivirus-mediated knockdown of FoxP1, FoxP2, or FoxP4 in area X of juvenile zebra finches

P Norton, P Barschke, C Scharff… - Journal of …, 2019 - Soc Neuroscience
Mutations in the transcription factors FOXP1 and FOXP2 are associated with speech
impairments. FOXP1 is additionally linked to cognitive deficits, as is FOXP4. These FoxP …

Autism-linked gene FoxP1 selectively regulates the cultural transmission of learned vocalizations

F Garcia-Oscos, TMI Koch, H Pancholi, M Trusel… - Science …, 2021 - science.org
Autism spectrum disorders (ASDs) are characterized by impaired learning of social skills
and language. Memories of how parents and other social models behave are used to guide …

The language-related transcription factor FOXP2 is post-translationally modified with small ubiquitin-like modifiers

SB Estruch, SA Graham, P Deriziotis, SE Fisher - Scientific reports, 2016 - nature.com
Mutations affecting the transcription factor FOXP2 cause a rare form of severe speech and
language disorder. Although it is clear that sufficient FOXP2 expression is crucial for normal …

Differential and overlapping pattern of Foxp1 and Foxp2 expression in the striatum of adult mouse brain

WL Fong, HY Kuo, HL Wu, SY Chen, FC Liu - Neuroscience, 2018 - Elsevier
Genetic mutations of FOXP1 and FOXP2 are associated with neurodevelopmental diseases.
It is important to characterize the cell types that express Foxp1 and Foxp2 in the brain. Foxp1 …

Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes, VLDLR and CNTNAP2 in the Zebra Finch Song System

E Mendoza, C Scharff - Frontiers in molecular neuroscience, 2017 - frontiersin.org
The Forkhead transcription factor FOXP2 is implicated in speech perception and production.
The avian homolog, FoxP2 contributes to song learning and production in birds. In human …