[HTML][HTML] Ketamine for pain

K Jonkman, A Dahan, T van de Donk, L Aarts… - …, 2017 - ncbi.nlm.nih.gov
The efficacy of the N-methyl-D-aspartate receptor antagonist ketamine as an analgesic
agent is still under debate, especially for indications such as chronic pain. To understand the …

Pharmacokinetic and pharmacodynamic considerations for NMDA-receptor antagonist ketamine in the treatment of chronic neuropathic pain: an update of the most …

J Kamp, M Van Velzen, E Olofsen, M Boon… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: Chronic neuropathic pain (NP) is an incapacitating illness caused by a lesion of
the somatosensory nervous system and is associated with several diseases or syndromes …

[HTML][HTML] Obesity by high-fat diet increases pain sensitivity by reprogramming branched-chain amino acid catabolism in dorsal root ganglia

N Lian, K Luo, H Xie, Y Kang, K Tang, P Lu… - Frontiers in Nutrition, 2022 - frontiersin.org
Obesity is a significant health concern as a result of poor-quality diet, for example, high-fat
diet (HFD). Although multiple biological and molecular changes have been identified to …

[HTML][HTML] Obesity and incident prescription opioid use in the US, 2000–2015

A Stokes, DJ Lundberg, K Hempstead, KM Berry… - American journal of …, 2020 - Elsevier
Introduction Prior studies have identified associations between obesity and numerous
conditions that increase risks for chronic pain. However, the impact of obesity on prescription …

[HTML][HTML] The effect of body mass index on thoracic paravertebral block analgesia after video-assisted thoracoscopic surgery; a prospective interventional study

EN Zengin, A Alagöz, H Yiğit, H Sazak, S Şekerci… - BMC …, 2023 - Springer
Background To investigate the effects of body mass index (BMI) on intensity postoperative
pain in patients who underwent thoracic paravertebral block (TPVB) for postoperative …

Neuroendocrine and neuroimmune mechanisms underlying comorbidity of pain and obesity

DH Zhang, YH Fan, YQ Zhang, H Cao - Life Sciences, 2023 - Elsevier
Pain and obesity, as well as their associated impairments, are major health concerns.
Understanding the relationship between the two is the focus of a growing body of research …

Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine

P Simons, R van der Schrier, M van Lemmen… - …, 2023 - pubs.asahq.org
Background Oliceridine is a G protein–biased µ-opioid, a drug class that is associated with
less respiratory depression than nonbiased opioids, such as morphine. The authors …

[HTML][HTML] Deleterious effects of higher body mass index on subjective and objective measures of chemotherapy-induced peripheral neuropathy in cancer survivors

I Petrovchich, KM Kober, L Wagner, SM Paul… - Journal of pain and …, 2019 - Elsevier
Context Recent, albeit, limited evidence suggests that body mass index (BMI) may be a
modifiable risk factor to reduce the deleterious effects of chemotherapy-induced peripheral …

[HTML][HTML] Opioid Analgesics after Bariatric Surgery: A Scoping Review to Evaluate Physiological Risk Factors for Opioid-Related Harm

SCM Wuyts, B Torensma, AFA Schellekens… - Journal of clinical …, 2023 - mdpi.com
The persisting use of opioids following bariatric surgery has emerged as a prevalent
complication, heightening the probability of opioid-related harm (ORM), such as opioid …

[HTML][HTML] Pain sensitivity does not differ between obese and healthy weight individuals

NM Emerson, H Nahman-Averbuch, JL Peugh… - Pain …, 2021 - journals.lww.com
Objectives: The aim of this study was to determine whether pain-free obese individuals
display altered pain responses to acute noxious stimuli, thus raising the possibility of greater …