Enhancing the stability of active pharmaceutical ingredients by the cocrystal strategy

L Liu, JR Wang, X Mei - CrystEngComm, 2022 - pubs.rsc.org
Cocrystallization has been recognized as one of the most successful approaches to address
the stability problems of active pharmaceutical ingredients (APIs) in the past few decades …

In-silico methods of cocrystal screening: A review on tools for rational design of pharmaceutical cocrystals

A Kumar, A Nanda - Journal of Drug Delivery Science and Technology, 2021 - Elsevier
Pharmaceutical cocrystals represent a distinctive class of crystal engineered
multicomponent systems consisting an API and a crystal former non-covalently linked …

Differentiating intramolecular spodium bonds from coordination bonds in two polynuclear zinc (II) Schiff base complexes

T Basak, RM Gomila, A Frontera, S Chattopadhyay - CrystEngComm, 2021 - pubs.rsc.org
Two new zinc (II) complexes,[{N (CN) 2} Zn (L1) Zn {μ-1, 5-N (CN) 2}] 2 (1) and [{μ-1, 5-N
(CN) 2}{N (CN) 2} Zn (L2) Zn {μ-1, 5-N (CN) 2}] n (2){H2L1= 2, 2′-[(2, 2-dimethyl-1, 3 …

[HTML][HTML] Intramolecular spodium bonds in Zn (II) complexes: insights from theory and experiment

M Karmakar, A Frontera, S Chattopadhyay… - International Journal of …, 2020 - mdpi.com
Two new dinuclear zinc (II) complexes,[Zn2 (µ 1, 3-OAc)(L1) 2] I· MeOH (1) and [Zn2 (µ 1, 3-
OAc)(L2)(NCS)](2),(where HL1= 2-(((3-(dimethylamino) propyl) amino) methyl)-6-methoxy …

[HTML][HTML] Amorphous Pterostilbene Delivery Systems Preparation—Innovative Approach to Preparation Optimization

N Rosiak, E Tykarska, J Cielecka-Piontek - Pharmaceutics, 2023 - mdpi.com
The aim of our research was to improve the solubility and antioxidant activity of pterostilbene
(PTR) by developing a novel amorphous solid dispersion (ASD) with Soluplus®(SOL). DSC …

A novel, extremely bioavailable cocrystal of pterostilbene

L Bofill, R Barbas, D de Sande… - Crystal Growth & …, 2021 - ACS Publications
New multicomponent solid forms of the nutraceutical pterostilbene have been discovered
and characterized through experimental cocrystal screening. Among the coformers tested …

Intermolecular interactions in antipyrine-like derivatives 2-halo-N-(1, 5-dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1 H-pyrazol-4-yl) benzamides: X-ray structure, Hirshfeld …

A Saeed, A Khurshid, U Flörke, GA Echeverría… - New Journal of …, 2020 - pubs.rsc.org
The synthesis, X-ray structure characterization, Hirshfeld surface analysis and DFT
calculations of two new antipyrine derivatives are reported herein. Particularly, 2-bromo-N …

Intriguing π-interactions involving aromatic neutrals, aromatic cations and semiconducting behavior in a pyridinium-carboxylate salt

P Das, S Islam, D Das, PP Ray, SK Seth - Journal of Molecular Structure, 2023 - Elsevier
A new pyridinium-carboxylate salt (1) has been synthesized and characterized by elemental
analysis, spectroscopy, electrical studies, and single-crystal X-ray diffraction. X-ray structure …

Synthesis and crystal structure of the simultaneous binding of Ni (ii) cation and chloride by the protonated 2, 4, 6 tris-(2-pyridyl)-1, 3, 5 triazine ligand: theoretical …

P Pal, K Das, A Hossain, RM Gomila… - New Journal of …, 2021 - pubs.rsc.org
A new octahedral Ni (II) complex 1 of protonated ligand Htptz+ (tptz: 2, 4, 6-tris (2-pyridyl)-1,
3, 5-triazine) has been synthesized and characterized by single crystal X-ray analysis. It is …

Halogen and Hydrogen Bonding Interplay Triggered Reversible Phase Transformations through Water Release/Uptake: X-ray Powder Diffraction Studies on Halogen …

S Saha, EV Murashova, VV Chernyshev… - Crystal Growth & …, 2024 - ACS Publications
The inclusion of water in organic crystals is more frequent compared to other solvents, given
its smaller size and excellent ability of hydrogen bonding with organic molecules. This work …