Amyloid precursor protein processing and Alzheimer's disease
RJ O'brien, PC Wong - Annual review of neuroscience, 2011 - annualreviews.org
Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …
Brain foods: the effects of nutrients on brain function
F Gómez-Pinilla - Nature reviews neuroscience, 2008 - nature.com
It has long been suspected that the relative abundance of specific nutrients can affect
cognitive processes and emotions. Newly described influences of dietary factors on …
cognitive processes and emotions. Newly described influences of dietary factors on …
Disruption of circadian clocks has ramifications for metabolism, brain, and behavior
Circadian (daily) rhythms are present in almost all plants and animals. In mammals, a brain
clock located in the hypothalamic suprachiasmatic nucleus maintains synchrony between …
clock located in the hypothalamic suprachiasmatic nucleus maintains synchrony between …
Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function
ME Bocarsly, M Fasolino, GA Kane… - Proceedings of the …, 2015 - National Acad Sciences
Obesity is a major public health problem affecting overall physical and emotional well-being.
Despite compelling data suggesting an association between obesity and cognitive …
Despite compelling data suggesting an association between obesity and cognitive …
Cognition from the body-brain partnership: exaptation of memory
Examination of cognition has historically been approached from language and introspection.
However, human language–dependent definitions ignore the evolutionary roots of brain …
However, human language–dependent definitions ignore the evolutionary roots of brain …
Stress, neurotransmitters, corticosterone and body–brain integration
F Mora, G Segovia, A Del Arco, M de Blas, P Garrido - Brain research, 2012 - Elsevier
Stress can be defined as a brain–body reaction towards stimuli arising from the environment
or from internal cues that are interpreted as a disruption of homeostasis. The organization of …
or from internal cues that are interpreted as a disruption of homeostasis. The organization of …
The blood–brain barrier as an endocrine tissue
WA Banks - Nature Reviews Endocrinology, 2019 - nature.com
The blood–brain barrier (BBB) was first noted for its ability to prevent the unregulated
exchange of substances between the blood and the central nervous system (CNS). Over …
exchange of substances between the blood and the central nervous system (CNS). Over …
The leptin hypothesis of depression: a potential link between mood disorders and obesity?
XY Lu - Current opinion in pharmacology, 2007 - Elsevier
The adipose-derived hormone leptin is well known for its function in the control of energy
homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of …
homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of …
Impaired CNS leptin action is implicated in depression associated with obesity
N Yamada, G Katsuura, Y Ochi, K Ebihara… - …, 2011 - academic.oup.com
Recent epidemiological studies indicate that obesity increases the incidence of depression.
We examined the implication of leptin for obesity-associated depression. Leptin induced …
We examined the implication of leptin for obesity-associated depression. Leptin induced …
Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β …
JC Garza, M Guo, W Zhang, XY Lu - Molecular psychiatry, 2012 - nature.com
Stress and glucocorticoid stress hormones inhibit neurogenesis, whereas antidepressants
increase neurogenesis and block stress-induced decrease in neurogenesis. Our previous …
increase neurogenesis and block stress-induced decrease in neurogenesis. Our previous …