Molecular and metabolic mechanisms of cardiac dysfunction in diabetes

CH Mandavia, AR Aroor, VG DeMarco, JR Sowers - Life sciences, 2013 - Elsevier
Diabetes mellitus type 2 (T2DM) is a widespread chronic medical condition with prevalence
bordering on the verge of an epidemic. It is of great concern that cardiovascular disease is …

Endothelial function in pre-diabetes, diabetes and diabetic cardiomyopathy: a review

M Matteo Ciccone, P Scicchitano, M Cameli… - Journal of Diabetes & …, 2014 - iris.unimore.it
Diabetes mellitus worsens cardiovascular risk profile of affected individuals. Its worldwide
increasing prevalence and its negative influences on vascular walls morphology and …

Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats

J Roslan, N Giribabu, K Karim, N Salleh - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Introduction Quercetin is known to possess beneficial effects in ameliorating diabetic
complications, however the mechanisms underlying cardioprotective effect of this compound …

[PDF][PDF] Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats

BY Aju, R Rajalakshmi, S Mini - Heliyon, 2019 - cell.com
Moringa oleifera is a medicinal plant with great therapeutic potential. The leaves of Moringa
oleifera are used by Indians in herbal medicines to treat diabetes. The present study is …

[HTML][HTML] Diabetic cardiomyopathy: impact of biological sex on disease development and molecular signatures

R Toedebusch, A Belenchia, L Pulakat - Frontiers in physiology, 2018 - frontiersin.org
Diabetic cardiomyopathy refers to a unique set of heart-specific pathological variables
induced by hyperglycemia and insulin resistance. Given that cardiovascular disease (CVD) …

[HTML][HTML] Rutin administration attenuates myocardial dysfunction in diabetic rats

JFC Guimaraes, BP Muzio, CM Rosa… - Cardiovascular …, 2015 - Springer
Background Oxidative stress plays a major role in diabetic cardiomyopathy pathogenesis.
Anti-oxidant therapy has been investigated in preventing or treating several diabetic …

[HTML][HTML] Carvedilol alleviates diabetic cardiomyopathy in diabetic rats

W Zheng, D Li, X Gao, W Zhang… - Experimental and …, 2019 - spandidos-publications.com
Diabetic cardiomyopathy (DCM) is characterized by structural and functional changes in the
myocardium. Several studies have revealed that myocardial apoptosis and fibrosis occur …

Low molecular weight fucoidan alleviates cardiac dysfunction in diabetic Goto‐Kakizaki rats by reducing oxidative stress and cardiomyocyte apoptosis

X Yu, Q Zhang, W Cui, Z Zeng, W Yang… - Journal of diabetes …, 2014 - Wiley Online Library
Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction and cardiomyocyte
apoptosis. Oxidative stress is suggested to be the major contributor to the development of …

[HTML][HTML] Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress

CT Zhao, M Wang, CW Siu, YL Hou, T Wang… - Cardiovascular …, 2012 - Springer
Abstract Background Endothelial progenitor cells (EPCs) are responsible for angiogenesis
and maintenance of microvascular integrity, the number of EPCs is correlated with oxidative …

Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study

F Shaher, S Wang, H Qiu, Y Hu, Y Zhang… - Diabetes, Metabolic …, 2020 - Taylor & Francis
Background Ganoderma lucidum spores (GLS) exhibit disease prevention properties, but no
study has been carried out on the anti-diabetic cardiomyopathy property of GLS. The aim of …