[HTML][HTML] Heparin, heparan sulphate and the TGF-β cytokine superfamily
CC Rider, B Mulloy - Molecules, 2017 - mdpi.com
Of the circa 40 cytokines of the TGF-β superfamily, around a third are currently known to bind
to heparin and heparan sulphate. This includes TGF-β1, TGF-β2, certain bone …
to heparin and heparan sulphate. This includes TGF-β1, TGF-β2, certain bone …
The clinical use of bone morphogenetic proteins revisited: a novel biocompatible carrier device OSTEOGROW for bone healing
S Vukicevic, H Oppermann, D Verbanac… - International …, 2014 - Springer
Purpose The purpose of this study was to revise the clinical use of commercial BMP2
(Infuse) and BMP7 (Osigraft) based bone devices and explore the mechanism of action and …
(Infuse) and BMP7 (Osigraft) based bone devices and explore the mechanism of action and …
Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells
L Ling, ET Camilleri, T Helledie, RM Samsonraj… - Gene, 2016 - Elsevier
Chronic use of heparin as an anti-coagulant for the treatment of thrombosis or embolism
invokes many adverse systemic events including thrombocytopenia, vascular reactions and …
invokes many adverse systemic events including thrombocytopenia, vascular reactions and …
[HTML][HTML] A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with …
D Durdevic, T Vlahovic, S Pehar, D Miklic… - Bone, 2020 - Elsevier
Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but
treating trabecular bone defects with a BMP based therapeutic remains controversial. Here …
treating trabecular bone defects with a BMP based therapeutic remains controversial. Here …
Learning from BMPs and their biophysical extracellular matrix microenvironment for biomaterial design
It is nowadays well-accepted that the extracellular matrix (ECM) is not a simple reservoir for
growth factors but is an organization center of their biological activity. In this review, we focus …
growth factors but is an organization center of their biological activity. In this review, we focus …
[HTML][HTML] Regulated entry of hepatitis C virus into hepatocytes
Z Miao, Z Xie, J Miao, J Ran, Y Feng, X Xia - Viruses, 2017 - mdpi.com
Hepatitis C virus (HCV) is a model for the study of virus–host interaction and host cell
responses to infection. Virus entry into hepatocytes is the first step in the HCV life cycle, and …
responses to infection. Virus entry into hepatocytes is the first step in the HCV life cycle, and …
Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo
Hepcidin controls systemic iron availability, and its excess contributes to the anemia of
chronic diseases, the most prevalent anemia in hospitalized patients. We previously …
chronic diseases, the most prevalent anemia in hospitalized patients. We previously …
[HTML][HTML] Iron supplementation therapy, a friend and foe of mycobacterial infections?
R Agoro, C Mura - Pharmaceuticals, 2019 - mdpi.com
Iron is an essential element that is required for oxygen transfer, redox, and metabolic
activities in mammals and bacteria. Mycobacteria, some of the most prevalent infectious …
activities in mammals and bacteria. Mycobacteria, some of the most prevalent infectious …
[HTML][HTML] Domains with highest heparan sulfate–binding affinity reside at opposite ends in BMP2/4 versus BMP5/6/7: Implications for function
PC Billings, E Yang, C Mundy, M Pacifici - Journal of Biological Chemistry, 2018 - ASBMB
Signaling proteins, including bone morphogenetic proteins (BMPs), specifically interact with
heparan sulfate (HS). These interactions regulate protein distribution and function and are …
heparan sulfate (HS). These interactions regulate protein distribution and function and are …
A 3D-printed bioactive polycaprolactone scaffold assembled with core/shell microspheres as a sustained BMP2-releasing system for bone repair
W Zhuang, G Ye, J Wu, L Wang, G Fang, Z Ye… - Biomaterials …, 2022 - Elsevier
Integration of biological factors and hierarchical rigid scaffolds is of great interest in bone
tissue engineering for fabrication of biomimetic constructs with high physical and biological …
tissue engineering for fabrication of biomimetic constructs with high physical and biological …