Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Cell death was once believed to be the result of one of two distinct processes, apoptosis
(also known as programmed cell death) or necrosis (uncontrolled cell death); in recent …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Acetaminophen (APAP) overdose is the predominant cause of acute liver failure in the
United States. Toxicity begins with a reactive metabolite that binds to proteins. In rodents …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

Background & Aims Hepatic ischemia-reperfusion injury (IRI) is a major complication of
hemorrhagic shock, liver resection and transplantation. YAP, a key downstream effector of …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

High-mobility group box 1 (HMGB1) is a nuclear factor that is released extracellularly as a
late mediator of lethality in sepsis as well as after necrotic, but not apoptotic, death. Here we …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …

TNF-α activates several intracellular pathways to regulate inflammation, cell death, and
proliferation. In the liver, TNF-α is not only a mediator of hepatotoxicity but also contributes to …