Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Despite long-term and widespread use of deep brain stimulation (DBS) in a variety of
neurological conditions, the underlying mechanisms of action have been elusive. Growing …

Parkinson's disease (PD) is characterised by the emergence of beta frequency oscillatory
synchronisation across the cortico-basal-ganglia circuit. The relationship between the …

Exaggerated basal ganglia beta activity (13–35 Hz) is commonly found in patients with
Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of …

Introduction & objectives Adaptive deep brain stimulation (aDBS) uses feedback from brain
signals to guide stimulation. A recent acute trial of unilateral aDBS showed that aDBS can …

Closed-loop neuromodulation systems aim to treat a variety of neurological conditions by
delivering and adjusting therapeutic electrical stimulation in response to a patient's neural …

Enhanced beta‐band activity recorded in patients suffering from Parkinson's Disease (PD)
has been described as a potential physiomarker for disease severity. Beta power is …

Synchronised neuronal oscillations at beta frequencies are prevalent in the human motor
system, but their function is unclear. In this Opinion article, we propose that the levels of beta …

Parkinson's disease is a common and disabling disorder of movement owing to
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …

Chronic dopamine depletion in Parkinson's disease leads to progressive motor and
cognitive impairment, which is associated with the emergence of characteristic patterns of …