A half-century of research on tuberculosis: Successes and challenges
BR Bloom - Journal of Experimental Medicine, 2023 - rupress.org
Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …
global health problem, particularly in low-and middle-income countries. Understanding the …
The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …
Airway T cells are a correlate of iv Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques
Summary Bacille Calmette-Guerin (BCG), the only approved Mycobacterium tuberculosis
(Mtb) vaccine, provides limited durable protection when administered intradermally …
(Mtb) vaccine, provides limited durable protection when administered intradermally …
Recent updates on correlates of vaccine-induced protection
SA Plotkin - Frontiers in Immunology, 2023 - frontiersin.org
Correlates of protection are key for vaccine development against any pathogen. In this paper
we summarize recent information about correlates for vaccines against dengue, Ebola …
we summarize recent information about correlates for vaccines against dengue, Ebola …
Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights
Tuberculosis has affected humankind for thousands of years, but a deeper understanding of
its cause and transmission only arose after Robert Koch discovered Mycobacterium …
its cause and transmission only arose after Robert Koch discovered Mycobacterium …
Shigella induces epigenetic reprogramming of zebrafish neutrophils
Trained immunity is a long-term memory of innate immune cells, generating an improved
response upon reinfection. Shigella is an important human pathogen and inflammatory …
response upon reinfection. Shigella is an important human pathogen and inflammatory …
Tuberculosis prevention: current strategies and future directions
A Vasiliu, L Martinez, RK Gupta, Y Hamada… - Clinical Microbiology …, 2023 - Elsevier
Background An estimated one fourth of the world's population is infected with
Mycobacterium tuberculosis, and 5–10% of those infected develop tuberculosis in their …
Mycobacterium tuberculosis, and 5–10% of those infected develop tuberculosis in their …
[HTML][HTML] Blood transcriptional correlates of BCG-induced protection against tuberculosis in rhesus macaques
Blood-based correlates of vaccine-induced protection against tuberculosis (TB) are urgently
needed. Here, we analyze the blood transcriptome of rhesus macaques immunized with …
needed. Here, we analyze the blood transcriptome of rhesus macaques immunized with …
Immune cells, gut microbiota, and vaccines: a gender perspective
P Rio, M Caldarelli, M Chiantore, F Ocarino, M Candelli… - Cells, 2024 - mdpi.com
The development of preventive and therapeutic vaccines has played a crucial role in
preventing infections and treating chronic and non-communicable diseases, respectively …
preventing infections and treating chronic and non-communicable diseases, respectively …
Tuberculosis infection in children and adolescents
B Tchakounte Youngui, BK Tchounga, SM Graham… - Pathogens, 2022 - mdpi.com
The burden of tuberculosis (TB) in children and adolescents remains very significant.
Several million children and adolescents are infected with TB each year worldwide following …
Several million children and adolescents are infected with TB each year worldwide following …