The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone …

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …

Background The gut-brain axis and the intestinal microbiota are emerging as key players in
health and disease. Shifts in intestinal microbiota composition affect a variety of systems; …

The structural properties of biomaterials play crucial roles in guiding cell behavior and
influencing immune responses against the material. We fabricated electrospun membranes …

Initially identified as a T lymphocyte-elicited inhibitor of macrophage motility, macrophage
migration inhibitory factor (MIF) has since been found to be expressed by nearly every …

Sepsis-induced AKI (acute kidney injury) is considered an inflammation-related disease with
high mortality. LPS-induced (Lipopolysaccharide) TLR4-NFκB pathway activation plays an …

The application of tumor immunotherapy to glioblastoma (GBM) is limited by an
unprecedented degree of immune suppression due to factors that include high numbers of …

Organ fibrogenesis is characterized by a common pathophysiological final pathway
independent of the underlying progressive disease of the respective organ. This makes it …

Macrophage migration inhibitory factor (MIF) is an upstream regulator of innate immunity, but
its expression is increased in some cancers via stabilization with HSP90-associated …

Renal inflammation is an initial pathological process during progressive renal injury
regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly …