Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

The eye contains a complex network of physiological information and biomarkers for
monitoring disease and managing health, and ocular devices can be used to effectively …

Bacteria carry diverse genetic systems to defend against viral infection, some of which are
found within prophages where they inhibit competing viruses. Phage satellites pose …

Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

Diet-induced metabolic endotoxemia is an important factor in the development of many
chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents …

Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading
to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and …

The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …

Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …

The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea,
and protozoans, bringing to the host organism a dowry of cells and genes more numerous …