Exploring tissue architecture using spatial transcriptomics
Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …
cellular arrangements in multicellular organisms has far-reaching implications for research …
[HTML][HTML] The interaction between ferroptosis and lipid metabolism in cancer
D Li, Y Li - Signal transduction and targeted therapy, 2020 - nature.com
Ferroptosis is a new form of programmed cell death characterized by the accumulation of
iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that …
iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that …
STOmicsDB: a comprehensive database for spatial transcriptomics data sharing, analysis and visualization
Recent technological developments in spatial transcriptomics allow researchers to measure
gene expression of cells and their spatial locations at the single-cell level, generating …
gene expression of cells and their spatial locations at the single-cell level, generating …
SPARK-X: non-parametric modeling enables scalable and robust detection of spatial expression patterns for large spatial transcriptomic studies
Spatial transcriptomic studies are becoming increasingly common and large, posing
important statistical and computational challenges for many analytic tasks. Here, we present …
important statistical and computational challenges for many analytic tasks. Here, we present …
Rapid 3D bioprinting of glioblastoma model mimicking native biophysical heterogeneity
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor characterized by high
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …
Pathologygan: Learning deep representations of cancer tissue
Histopathological images of tumors contain abundant information about how tumors grow
and how they interact with their micro-environment. Better understanding of tissue …
and how they interact with their micro-environment. Better understanding of tissue …
Applicability of spatial transcriptional profiling to cancer research
R Bassiouni, LD Gibbs, DW Craig, JD Carpten… - Molecular cell, 2021 - cell.com
Spatial transcriptional profiling provides gene expression information within the important
anatomical context of tissue architecture. This approach is well suited to characterizing solid …
anatomical context of tissue architecture. This approach is well suited to characterizing solid …
Mapping spatiotemporal heterogeneity in tumor profiles by integrating high-throughput imaging and omics analysis
PA Patkulkar, AR Subbalakshmi, MK Jolly… - ACS …, 2023 - ACS Publications
Intratumoral heterogeneity associates with more aggressive disease progression and worse
patient outcomes. Understanding the reasons enabling the emergence of such …
patient outcomes. Understanding the reasons enabling the emergence of such …
STOmicsDB: a database of spatial transcriptomic data
Recent technological development in spatial transcriptomics allows researchers to measure
gene expression of cells and their spatial locations at the almost single-cell level, which …
gene expression of cells and their spatial locations at the almost single-cell level, which …
The mitochondrial citrate carrier SLC25A1/CIC and the fundamental role of citrate in cancer, inflammation and beyond
R Mosaoa, A Kasprzyk-Pawelec, HR Fernandez… - Biomolecules, 2021 - mdpi.com
The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in
a growing list of human diseases. CIC belongs to a large family of nuclear-encoded …
a growing list of human diseases. CIC belongs to a large family of nuclear-encoded …