Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Histone deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that
play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis …

Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and
have a key role in the epigenetic regulation of gene expression. In addition, the activity of …

In our quest to understand why dimethyl sulfoxide (DMSO) can cause growth arrest and
terminal differentiation of transformed cells, we followed a path that led us to discover …

HER2 is a transmembrane oncoprotein encoded by the HER2/neu gene and is
overexpressed in approximately 20 to 25% of invasive breast cancers. It can be …

This review focuses on the posttranslational acetylation of non-histone proteins, which
determines vital regulatory processes. The recruitment of histone acetyltransferases and …

Epigenetic alterations, along with genetic alterations, have long been regarded as the most
important mechanism participating in carcinogenesis. DNA methylation, histone …

The hydroxamic acid (HAA) analogue pan-histone deacetylase (HDAC) inhibitors (HDIs)
LAQ824 and LBH589 have been shown to induce acetylation and inhibit the ATP binding …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The path to the discovery of suberoylanilide hydroxamic acid (SAHA, vorinostat) began over
three decades ago with our studies designed to understand why dimethylsulfoxide causes …