PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets
H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …
disease, has emerged as a major public health problem, more efficient therapeutics of which …
Mechanotransduction and extracellular matrix homeostasis
JD Humphrey, ER Dufresne… - Nature reviews Molecular …, 2014 - nature.com
Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …
environmental cues and respond to them to promote homeostasis, including maintenance of …
[HTML][HTML] Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) and its progressive form nonalcoholic
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …
PPARs and nonalcoholic fatty liver disease
KHH Liss, BN Finck - Biochimie, 2017 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) encompasses a range of liver pathology ranging
from simple steatosis to varying degrees of inflammation, hepatocyte injury and fibrosis …
from simple steatosis to varying degrees of inflammation, hepatocyte injury and fibrosis …
A role of peroxisome proliferator‐activated receptor γ in non‐alcoholic fatty liver disease
J Skat‐Rørdam, D Højland Ipsen… - Basic & clinical …, 2019 - Wiley Online Library
Non‐alcoholic fatty liver disease is becoming a major health burden, as prevalence
increases and there are no approved treatment options. Thiazolidinediones target the …
increases and there are no approved treatment options. Thiazolidinediones target the …
Pathogenesis and novel treatment options for non-alcoholic steatohepatitis
Non-alcoholic fatty liver disease affects 20–40% of the population. Its active form, non-
alcoholic steatohepatitis (NASH), is characterised by hepatocyte injury, liver inflammation …
alcoholic steatohepatitis (NASH), is characterised by hepatocyte injury, liver inflammation …
Roles of PPARs in NAFLD: potential therapeutic targets
Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increasing prevalence
due to the obesity epidemic. Hence, NAFLD represents a rising threat to public health …
due to the obesity epidemic. Hence, NAFLD represents a rising threat to public health …
[HTML][HTML] CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis
Background & Aims Perpetuate liver inflammation is crucial in the pathogenesis of non-
alcoholic steatohepatitis (NASH). Expression of CXCL10, a pro-inflammatory cytokine …
alcoholic steatohepatitis (NASH). Expression of CXCL10, a pro-inflammatory cytokine …
[HTML][HTML] Transcriptional regulation of metabolic pathways via lipid-sensing nuclear receptors PPARs, FXR, and LXR in NASH
M Cariello, E Piccinin, A Moschetta - Cellular and molecular …, 2021 - Elsevier
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) comprises a wide spectrum of liver
injuries from simple steatosis to steatohepatitis and cirrhosis. Non-Alcoholic Steatohepatitis …
injuries from simple steatosis to steatohepatitis and cirrhosis. Non-Alcoholic Steatohepatitis …
[HTML][HTML] A randomised, double-blind, placebo-controlled, multi-centre, dose-range, proof-of-concept, 24-week treatment study of lanifibranor in adult subjects with non …
B Pierre, B Elisabetta, R Vlad, HM Philippe… - Contemporary Clinical …, 2020 - Elsevier
Background Non-alcoholic steatohepatitis (NASH), a multifactorial disease, can progress to
hepatic fibrosis and cirrhosis. The Peroxysomal Proliferator-Activated Receptors, PPARα …
hepatic fibrosis and cirrhosis. The Peroxysomal Proliferator-Activated Receptors, PPARα …