Fibrin plays an essential role in hemostasis as both the primary product of the coagulation
cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Rotational thromboelastometry (ROTEM) is a point-of-care viscoelastic method and enables
to assess viscoelastic profiles of whole blood in various clinical settings. ROTEM-guided …

Background Effective treatment of trauma-induced coagulopathy is important; however, the
optimal therapy is still not known. We aimed to compare the efficacy of first-line therapy …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient. When these recommendations are implemented patient …

Background: Patients with substantive bleeding usually require transfusion and/or (re-)
operation. Red blood cell (RBC) transfusion is independently associated with a greater risk …

Background: Low fibrinogen levels are known to occur in trauma. However, the extent of
fibrinogen depletion during trauma hemorrhage, the response to replacement therapy and …

Introduction The understanding of coagulopathies in trauma has increased interest in
thromboelastography (TEG®) and thromboelastometry (ROTEM®), which promptly evaluate …