Calcium (Ca2+) release from intracellular stores controls numerous cellular processes,
including cardiac and skeletal muscle contraction, synaptic transmission and metabolism …

Amyotrophic lateral sclerosis (ALS) is a fatal adult‐onset disease primarily characterized by
upper and lower motor neuron degeneration, muscle wasting and paralysis. It is increasingly …

Muscle atrophy with weakness is a core feature of amyotrophic lateral sclerosis (ALS) that
has long been attributed to motor neuron loss alone. However, several studies in ALS …

Sporadic inclusion body myositis (IBM) is the most common primary myopathy in the elderly,
but its pathoetiology is still unclear. Perturbed myocellular calcium (Ca 2+) homeostasis can …

Amyotrophic lateral sclerosis (ALS) is a devastating neuromuscular disease characterized
by motor neuron loss and prominent skeletal muscle wasting. Despite more than one …

Selective motor neuron degeneration is a hallmark of amyotrophic lateral sclerosis (ALS).
Around 10% of all cases present as familial ALS (FALS), while sporadic ALS (SALS) …

Mutations in Cu/Zn superoxide dismutase (SOD1) are one of the genetic causes of
Amyotrophic Lateral Sclerosis (ALS). Although the primary symptom of ALS is muscle …

The abrupt cessation of ovarian hormone release is associated with declines in muscle
contractile function, yet the impact of gradual ovarian failure on muscle contractility across …

Animals require different types of muscle for survival, for example for circulation, motility,
reproduction and digestion. Much emphasis in the muscle field has been placed on …

Amyotrophic lateral sclerosis (ALS) arises from neuronal death due to complex interactions
of genetic, molecular, and environmental factors. Currently, only two drugs, riluzole and …