Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells
located in the endocrine pancreas in areas known as islets of Langerhans. The current …

Initially discovered as an impurity in insulin preparations, our understanding of the
hyperglycaemic hormone glucagon has evolved markedly over subsequent decades. With …

Oxyntomodulin is a product of the glucagon precursor, proglucagon, produced and released
from the endocrine L-cells of the gut after enzymatic processing by the precursor …

Enzyme-resistant long-acting forms of the gut-derived peptide hormones, glucose-
dependent insulinotropic polypeptide (GIP), xenin and oxyntomodulin (Oxm) have been …

Oxyntomodulin (OXM) is an endogenous peptide hormone secreted from the intestines
following nutrient ingestion that activates both glucagon-like peptide-1 (GLP-1) and …

Obesity and type 2 diabetes mellitus (T2DM) progress worldwide with detrimental effects on
several physiological systems including bone tissue mainly by affecting bone quality …

Aim To investigate the antidiabetic efficacy of enzymatically stable Peptide YY (PYY)
peptides from phylogenetically ancient fish. Materials and methods N‐terminally stabilized …

Recent studies have confirmed that locally released proglucagon derived gene products,
other than glucagon, have a major influence on pancreatic endocrine function. We assessed …

We investigated the direct effects on insulin releasing MIN6 cells of chronic exposure to GLP-
1, glucagon or a combination of both peptides secreted from GLUTag L-cell and αTC1. 9 …

Abstract Purpose of Study Although the current treatment option of exogenous insulin
administration for type 1 diabetes mellitus (T1DM) corrects hyperglycemia, it has its own …