Muscle wasting is associated with a wide range of catabolic diseases. This debilitating loss
of muscle mass and functional capacity reduces the quality of life and increases the risks of …

Duchenne muscular dystrophy is a devastating inherited neuromuscular disorder that affects
one in 3300 live male births. Although the responsible gene and its product, dystrophin …

Serum biomarkers in Duchenne muscular dystrophy (DMD) may provide deeper insights
into disease pathogenesis, suggest new therapeutic approaches, serve as acute read-outs …

The myostatin/activin type II receptor (ActRII) pathway has been identified to be critical in
regulating skeletal muscle size. Several other ligands, including GDF11 and the activins …

Becker muscular dystrophy (BMD) is a variant of dystrophin deficiency resulting from DMD
gene mutations. Phenotype is variable with loss of ambulation in late teenage or late mid-life …

Muscular dystrophies such as Duchenne muscular dystrophy (DMD) are usually
approached as dysfunctions of the affected skeletal myofibres and their force transmission …

Chronic kidney disease (CKD) and several other catabolic conditions are characterized by
increased circulating inflammatory cytokines, defects in IGF-1 signaling, abnormal muscle …

Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue
that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in …

The lack of myostatin promotes growth of skeletal muscle, and blockade of its activity has
been proposed as a treatment for various muscle-wasting disorders. Here, we have …

The transforming growth factor-beta (TGF-β) superfamily consists of a variety of cytokines
expressed in many different cell types including skeletal muscle. Members of this …