Cardiac arrhythmia is one of the most prevalent cardiovascular diseases worldwide, which
can occur alone or be triggered by other diseases, and it can be fatal in severe cases …

Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts
and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal …

Ferroptosis is one of the main mechanisms involved in different forms of acute kidney injury
(AKI), including cisplatin-induced AKI. However, it is not clear whether Cx43 has a regulatory …

Exosomes are nanosized vesicles that carry biologically diverse molecules for intercellular
communication. Researchers have been trying to engineer exosomes for therapeutic …

In the heart, connexins form gap junctions, hemichannels, and are also present within
mitochondria, with connexin 43 (Cx43) being the most prominent connexin in the ventricles …

Ventricular cardiac arrhythmia is a life threating condition arising from abnormal functioning
of many factors in concert. Animal models mirroring human electrophysiology are essential …

Heart failure (HF) is life-threatening disease due to electro-mechanical dysfunction
associated with hemodynamic overload, while alterations of extracellular matrix (ECM) …

Of increasing prevalence, diabetes is characterised by elevated blood glucose and chronic
inflammation that precedes the onset of multiple secondary complications, including those of …

Background Trametinib is a MEK1 (mitogen-activated extracellular signal-related kinase
kinase 1) inhibitor used in the treatment of BRAF (rapid accelerated fibrosarcoma B-type) …

The correlation between long-QT and connexin 43 (Cx43) status and localization in elderly
rats was determined to demonstrate a correlation between insulin resistance (IR), ischemia …