The skin provides both a physical barrier and an immunologic barrier to external threats. The
protective machinery of the skin has evolved to provide situation-specific responses to …

Asthma and asthma-related traits are complex diseases with strong genetic and
environmental components. Rapid progress in asthma genetics has led to the identification …

An enhanced Th2 immune response and the elaboration of cytokines such as IL-4, IL-13,
and IL-5 contribute to the induction of allergy and asthma. Interferon-γ, a Th1 cytokine, acts …

Asthma is a common, disabling inflammatory respiratory disease that has increased in
frequency and severity in developed nations. We review studies of murine allergic airway …

Abstract IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different
cell types and responsible for a broad range of biology and functions. Physiologically, Th2 …

Background Glioma is a rapidly progressive disease, and little is known about its etiology.
Atopic diseases are on the rise in western populations, with increasing interest on their long …

Psoriasis and atopic dermatitis are chronic and relapsing inflammatory diseases of the skin
associated with various immunologic abnormalities. Approximately 30% of psoriasis patients …

Asthma is a common respiratory disease that is characterized by variable airways
obstruction caused by acute and chronic bronchial inflammation; associated phenotypes …

BACKGROUND: The importance of IL-13 in the asthma paradigm is supported by increased
expression in human subjects, particularly in patients with mild-to-moderate asthma …

Asthma affects nearly 300 million people worldwide. The majority respond to inhaled
corticosteroid treatment with or without beta-adrenergic agonists. However, a subset of 5 to …