Heart disease and stroke statistics—2022 update: a report from the American Heart Association
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …
The genetics of obesity: from discovery to biology
The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …
Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity
SE Hampl, SG Hassink, AC Skinner, SC Armstrong… - …, 2023 - publications.aap.org
The current and long-term health of 14.4 million children and adolescents is affected by
obesity, 1, 2 making it one of the most common pediatric chronic diseases. 3–5 Long …
obesity, 1, 2 making it one of the most common pediatric chronic diseases. 3–5 Long …
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with …
incorporating nearly a quarter of a million cases, in which existing studies are integrated with …
[HTML][HTML] Adipose tissue and insulin resistance in obese
Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …
Human microglial state dynamics in Alzheimer's disease progression
Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …
Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
Direct medical costs of obesity in the United States and the most populous states
BACKGROUND: After a dramatic increase in prevalence over several decades, obesity has
become a major public health crisis in the United States. Research to date has consistently …
become a major public health crisis in the United States. Research to date has consistently …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
Obesity: global epidemiology and pathogenesis
M Blüher - Nature Reviews Endocrinology, 2019 - nature.com
The prevalence of obesity has increased worldwide in the past~ 50 years, reaching
pandemic levels. Obesity represents a major health challenge because it substantially …
pandemic levels. Obesity represents a major health challenge because it substantially …