Next generation sequencing and its applications in forensic genetics

C Børsting, N Morling - Forensic Science International: Genetics, 2015 - Elsevier
It has been almost a decade since the first next generation sequencing (NGS) technologies
emerged and quickly changed the way genetic research is conducted. Today, full genomes …

Improving human forensics through advances in genetics, genomics and molecular biology

M Kayser, P De Knijff - Nature Reviews Genetics, 2011 - nature.com
Forensic DNA profiling currently allows the identification of persons already known to
investigating authorities. Recent advances have produced new types of genetic markers …

[HTML][HTML] Developmental validation of the MiSeq FGx forensic genomics system for targeted next generation sequencing in forensic DNA casework and database …

AC Jäger, ML Alvarez, CP Davis, E Guzmán… - Forensic Science …, 2017 - Elsevier
Human DNA profiling using PCR at polymorphic short tandem repeat (STR) loci followed by
capillary electrophoresis (CE) size separation and length-based allele typing has been the …

Diverse somatic mutation patterns and pathway alterations in human cancers

Z Kan, BS Jaiswal, J Stinson, V Janakiraman, D Bhatt… - Nature, 2010 - nature.com
The systematic characterization of somatic mutations in cancer genomes is essential for
understanding the disease and for developing targeted therapeutics. Here we report the …

Ancient DNA from European early neolithic farmers reveals their near eastern affinities

W Haak, O Balanovsky, JJ Sanchez, S Koshel… - PLoS …, 2010 - journals.plos.org
In Europe, the Neolithic transition (8,000–4,000 bc) from hunting and gathering to
agricultural communities was one of the most important demographic events since the initial …

IrisPlex: a sensitive DNA tool for accurate prediction of blue and brown eye colour in the absence of ancestry information

S Walsh, F Liu, KN Ballantyne, M van Oven… - Forensic Science …, 2011 - Elsevier
A new era of 'DNA intelligence'is arriving in forensic biology, due to the impending ability to
predict externally visible characteristics (EVCs) from biological material such as those found …

Microhaplotypes in forensic genetics

F Oldoni, KK Kidd, D Podini - Forensic Science International: Genetics, 2019 - Elsevier
Microhaplotype loci (microhaps, MHs) are a novel type of molecular marker of less than 300
nucleotides, defined by two or more closely linked SNPs associated in multiple allelic …

Forensic trace DNA: a review

RAH Van Oorschot, KN Ballantyne, RJ Mitchell - Investigative genetics, 2010 - Springer
DNA analysis is frequently used to acquire information from biological material to aid
enquiries associated with criminal offences, disaster victim identification and missing …

Massive parallel sequencing in forensics: advantages, issues, technicalities, and prospects

D Ballard, J Winkler-Galicki, J Wesoły - International Journal of Legal …, 2020 - Springer
In the last decade, next-generation sequencing (NGS) technology, alternatively massive
parallel sequencing (MPS), was applied to all fields of biological research. Its introduction to …

Forensically relevant SNP classes

B Budowle, A Van Daal - Biotechniques, 2008 - Taylor & Francis
Forensic samples that contain too little template DNA or are too degraded require alternate
genetic marker analyses or approaches to what is currently used for routine casework …