Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles
for neuroscience research. They have two engineerable features: the capsid (outer protein …

Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Microglia, the resident immune cells of the brain, have emerged as crucial regulators of
synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse …

Sensitization of trigeminal ganglion neurons contributes to primary headache disorders such
as migraine, but the specific neuronal and non-neuronal trigeminal subtypes that are …

Human cortex transcriptomic studies have revealed a hierarchical organization of γ-
aminobutyric acid–producing (GABAergic) neurons from subclasses to a high diversity of …

The cardinal classes are a useful simplification of cortical interneuron diversity, but such
broad subgroupings gloss over the molecular, morphological, and circuit specificity of …

A barrier to advancing engineered adeno-associated viral vectors (AAVs) for precision
access to cell subtypes is a lack of high-throughput, high-resolution assays to characterize in …

Genetic intervention is increasingly being explored as a therapeutic option for debilitating
disorders of the central nervous system. The safety and efficacy of gene therapies rely upon …