Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease | NEJM Skip to main
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Nonalcoholic fatty liver disease (NAFLD) affects around a quarter of the global population,
paralleling worldwide increases in obesity and metabolic syndrome. NAFLD arises in the …

Attempts to define concepts and things date back to the time of Aristotle, around 2,400 years
ago, when he proposed that a definition should state the essential nature or being of …

Over 200 years ago, René Laennec published the first description of emphysema, an
important pathobiological element of what is today known as chronic obstructive pulmonary …

Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but
other determinants of the disease are incompletely understood. Clonal hematopoiesis of …

Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide,
is highly heritable. While COPD is clinically defined by applying thresholds to summary …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …