The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

Cocrystals, a long known but understudied class of crystalline solids, have attracted interest
from crystal engineers and pharmaceutical scientists in the past decade and are now an …

In recent years cocrystal formation has emerged as a viable strategy towards improving the
solubility and bioavailability of poorly soluble drugs. In this review the success of numerous …

Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Cocrystal engineering have been widely applied in pharmaceutical, chemistry and material
fields. However, how to effectively choose coformer has been a challenging task on …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient
are the major constraints during the development of new product. Various approaches have …

Cocrystal is a concept of the supramolecular chemistry which is gaining the extensive
interest of researchers from pharmaceutical and chemical sciences and of drug regulatory …