Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Genetic factors contribute to the phenotype of drug response. We systematically analyzed all
available pharmacogenetic data from Medline databases (1970–2003) on the impact that …

Objective: Response to specific depression treatments varies widely among individuals.
Understanding and predicting that variation could have great benefits for people living with …

In the last decade the serotonin transporter gene promoter polymorphism (5-HTTLPR) was
likely the most studied genetic variant as predictor of antidepressant response. Nevertheless …

The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …

This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The current 'fixed-dosage strategy'approach to medicine, means there is much inter-
individual variation in drug response. Pharmacogenetics is the study of how inter-individual …

Discovered and crystallized over sixty years ago, serotonin's important functions in the brain
and body were identified over the ensuing years by neurochemical, physiological and …

Personalized medicine—the adaptation of therapies based on an individual's genetic and
molecular profile—is one of the most promising aspects of modern medicine. The …