The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

The ATP: ADP ratio is a critical parameter of cellular energy status that regulates many
metabolic activities. Here we report an optimized genetically encoded fluorescent biosensor …

Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

ATP-sensitive potassium channels (K ATP) couple intracellular ATP levels with membrane
excitability. These channels play crucial roles in many essential physiological processes …

Survival in the wild requires organismal adaptations to the availability of nutrients.
Endosomes and lysosomes are key intracellular organelles that couple nutrition and …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

J. Neurochem.(2010) 10.1111/j. 1471‐4159.2010. 06580. x Abstract Nitric oxide (NO) and
carbon monoxide (CO) are well established as messenger molecules throughout the body …

In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel
activity provides a unique link between cellular energetics and electrical excitability. Over …